U-VUE Biomarker Datasheet - CD11c

Target:CD11c
Alternative Name:Integrin alpha-X
Clone:EP1347Y
Isotype:Rabbit IgG
Reactivity:Human
Main cell types:Myeloid-derived cells
Subcellular Location:Plasma membrane
Positive control:Tonsil, Spleen

B-lymphocyte surface antigen B1CD11c is expressed by dendritic cells, monocytes, macrophages, neutrophils, and some B cells. CD11c is one of four β2 integrins along with CD11a, C11b and CD11d. CD11c is a receptor for fibrinogen and functions in chemotaxis and cell adhesion. Integrins mediate

IHC: Anti-CD11c [EP1347Y] antibody staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-CD11c [EP1347Y] antibody conjugate staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-CD11c [EP1347Y] antibody conjugate staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Weber, M et al. “Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas–an immunohistochemical study.” British journal of cancer, vol. 113,3 (2015): 510-9. DOI: 10.1038/bjc.2015.212
  2. Wehrhan, Falk et al. “Increased malignancy of oral squamous cell carcinomas (oscc) is associated with macrophage polarization in regional lymph nodes – an immunohistochemical study.” BMC cancer, vol. 14 522. 21 Jul. 2014. DOI: 10.1186/1471-2407-14-522
  3. Yawalkar, Nikhil, et al. “Increased Expression of IL-12p70 and IL-23 by Multiple Dendritic Cell and Macrophage Subsets in Plaque Psoriasis.” Journal of Dermatological Science, Elsevier, 4 Mar. 2009. DOI: 10.1016/j.jdermsci.2009.01.003

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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