U-VUE Biomarker Datasheet - CD14

Target:CD14
Alternative Name:Monocyte differentiation antigen CD14
Clone:SP192
Isotype:Rabbit IgG
Reactivity:Human
Main cell types:Myeloid-derived cells (i.e. mature monocytes / macrophages)
Subcellular Location:Plasma membrane
Positive control:Tonsil, Spleen

CD14 is a pattern recognition receptor that detects the pathogen-assocaited molecular patterns found on the surface of microorganisms. It is a co-receptor located on the cell surface that mediates the innate immune response.

IHC: Anti-CD14 antibody [SP192] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-CD14 antibody conjugate [SP192] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-CD14 antibody conjugate [SP192] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Bajpai, Geetika et al. “The human heart contains distinct macrophage subsets with divergent origins and functions.” Nature medicine, vol. 24,8 (2018): 1234-1245. DOI: 10.1038/s41591-018-0059-x
  2. Takahashi, Yoshinobu et al. “Monocyte chemoattractant protein 1 expression and proliferation in primary central nervous system lymphoma.” Oncology letters, vol. 14,1 (2017): 264-270. DOI: 10.3892/ol.2017.6122
  3. Hamada, Daisuke et al. “Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus.” Arthritis & rheumatology (Hoboken, N.J.) vol. 68,6 (2016): 1392-402. DOI: 10.1002/art.39561

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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