U-VUE Biomarker Datasheet - CD15

Target:CD15
Alternative Name:X-hapten
Clone:Lei-M1 (aka MMA)
Isotype:Mouse IgM
Reactivity:Human
Main cell types:Myeloid-derived cells
Subcellular Location:Plasma membrane
Positive control:Tonsil, Spleen, Colon

CD15 is a cluster of cell surface glycoproteins and glycolipids, also known as 3-fucosyl-N-acetyl-lactosamine or Lewis X. CD15 is a carbohydrate adhesional molecule that functions in cell-to-cell recognition processes. It is reportedly expressed on the majority of granulocytes and small percentage of monocytes. In the context of myeloid-derived suppressor cells (MDSCs), the presence of CD15 and CD11b or CD33 can be used to identify polymorphonuclear MDSCs (PMN-MDSCs).

IHC: Anti-CD15 antibody [Leu-M1] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-CD15 antibody conjugate [Leu-M1] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-CD15 antibody conjugate [Leu-M1] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Pellegrini, Wilma, et al. “MMA Monoclonal Antibody Is a Superior Anti-CD15 Reagent for the Diagnosis of Classical Hodgkin’s Lymphoma.” Haematologica, 1 May 2007. DOI: 10.3324/haematol.11002
  2. Hoang, Mai P, et al. “Microcystic Adnexal Carcinoma: an Immunohistochemical Reappraisal.” Nature News, Nature Publishing Group, 7 Dec. 2007. DOI: 10.1038/modpathol.3801000

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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