U-VUE Biomarker Datasheet - CD163

Target:CD163
Alternative Name:Hemoglobin scavenger receptor
Clone:EPR19518
Isotype:Rabbit IgG
Reactivity:Human
Main cell types:Monocytes, macrophages, myeloid cells, bone marrow stromal cells, subset of erythroid progenitors
Subcellular Location:Plasma membrane
Positive control:Tonsil, Spleen

CD163 is a type I transmembrane protein of 130 KD molecular weight belonging to the group B of the scavenger receptor cysteine-rich superfamily. It is involved in the clearance and endocytosis of haptoglobin-hemoglobin complexes mostly expressed by monocytes and macrophages. This scavenging role plays a critical role in its anti-inflamatory response.

IHC: Anti-CD163 antibody [EPR19518] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-CD163 antibody conjugate [EPR19518] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-CD163 antibody conjugate [EPR19518] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Berthel, Anna et al. “Detailed resolution analysis reveals spatial T cell heterogeneity in the invasive margin of colorectal cancer liver metastases associated with improved survival.” Oncoimmunology, vol. 6,3 e1286436. 23 Feb. 2017. DOI: 10.1080/2162402X.2017.1286436
  2. Clement, Marc et al. “Tertiary Lymphoid Organs in Takayasu Arteritis.” Frontiers in immunology, vol. 7 158. 22 Apr. 2016. DOI: 10.3389/fimmu.2016.00158
  3. Sato, Yasunori, et al. “The PD‐1/PD‐L1 Axis May Be Aberrantly Activated in Occupational Cholangiocarcinoma.” Wiley Online Library, John Wiley & Sons, Ltd, 31 Jan. 2017. DOI: 10.1111/pin.12511

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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