U-VUE Biomarker Datasheet - CD19

Target:CD19
Alternative Name:B-lymphocyte antigen CD19
Clone:EPR5906
Isotype:Rabbit IgG
Reactivity:Human
Main cell types:B cells, follicular dendritic cells
Subcellular Location:Plasma membrane
Positive control:Tonsil, Spleen

CD19 is a transmembrane protein located on the surface of all B lineage cells, exept for plasma cells . This protein plays a role in regulating B cell development, activation and differentiation. In mature B cells this protein functions by forming a complex with CD21, CD81, and CD225. CD19 can also expressed on follicular dentritic cells and the majority of B cell malignancies, including B cell lymphomas.

IHC: Anti-CD19 antibody [EPR5906] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-CD19 antibody conjugate [EPR5906] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-CD19 antibody conjugate [EPR5906] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Griss, Johannes et al. “B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma.” Nature communications vol. 10,1 4186. 13 Sep. 2019, DOI: 10.1038/s41467-019-12160-2
  2. Ohtani H, Komeno T, Agatsuma Y, Kobayashi M, Noguchi M, Nakamura N. Follicular Dendritic Cell Meshwork in Angioimmunoblastic T-Cell Lymphoma Is Characterized by Accumulation of CXCL13(+) Cells. J Clin Exp Hematop. 2015;55(2):61-69. DOI: 10.3960/jslrt.55.61
  3. Hoyos, Valentina et al. “Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers.” Molecular therapy : the journal of the American Society of Gene Therapy vol. 23,9 (2015): 1497-506. DOI: 10.1038/mt.2015.110

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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