U-VUE Biomarker Datasheet - CD20

Target:CD20
Alternative Name:B-lymphocyte surface antigen B1
Clone:L26
Isotype:Mouse IgG2a
Reactivity:Human
Main cell types:B cells
Subcellular Location:Plasma membrane
Positive control:Tonsil, Spleen

CD20 is a B cell differentiation antigen expressed in B cell development from early pre-B cell stage to mature B cell stage but lost on differentiation in to plasma cells. Its role is in regulating B- cell activation, proliferation and differentiation.

IHC: Anti-CD20 antibody [L26] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-CD20 antibody conjugate [L26] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-CD20 antibody conjugate [L26] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Oberlin, Dominique et al. “Insulin-like growth factor I messenger RNA and protein are expressed in the human lymph node and distinctly confined to subtypes of macrophages, antigen-presenting cells, lymphocytes and endothelial cells.” Immunology, 2009 Nov;128(3):342-50. DOI: 10.1111/j.1365-2567.2009.03136.x
  2. Kitamura, Hiroshi. “Effect of Human Leukocyte Antigen Class I Expression of Tumor Cells on Outcome of Intravesical Instillation of Bacillus Calmette-Guerin Immunotherapy for Bladder Cancer.” Clinical Cancer Research, 2006 Aug 1;12(15):4641-4. DOI: 10.1158/1078-0432.CCR-06-0595
  3. Zen, Yoh. “Hepatotoxicity of Immune Checkpoint Inhibitors: A Histology Study of Seven Cases in Comparison with Autoimmune Hepatitis and Idiosyncratic Drug-Induced Liver Injury.” Modern Pathology, 2018 Jun;31(6):965-973. DOI: 10.1038/s41379-018-0013-y

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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