U-VUE Biomarker Datasheet - FoxP3

Target:FoxP3
Alternative Name:Forkhead box protein P3, Surfin
Clone:236A/E7
Isotype:Mouse IgG1
Reactivity:Human
Main cell types:Regulatory T cells
Subcellular Location:Nuclear
Positive control:Tonsil, Spleen, Lymph Node

FoxP3, or Forkhead Box P3 is a transcription factor important in the development and inhibitory function of regulatory T cells (Tregs). FoxP3 functions by inhibiting cytokine production and T cell effector function, thus playing a crucial role in maintanance of immunological tolerance and control of immune responses against tumors and pathogens.

IHC: Anti-FoxP3 antibody [236A/E7] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-FoxP3 antibody conjugate [236A/E7] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-FoxP3 antibody conjugate [236A/E7] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Takada, Koji et al. “Use of the tumor-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to combination therapy with pertuzumab, trastuzumab, and docetaxel for advanced HER2-positive breast cancer.” Journal of translational medicine, vol. 16,1 86. 3 Apr. 2018. DOI: 10.1186/s12967-018-1460-4
  2. Kaewkangsadan, Viriya et al. “Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (Th1, Th2) to immune-mediated tumour cell death induced by NAC.” BMC cancer, vol. 18,1 123. 2 Feb. 2018. DOI: 10.1186/s12885-018-4044-z
  3. Hecking, Thomas et al. “Tumoral PD-L1 expression defines a subgroup of poor-prognosis vulvar carcinomas with non-viral etiology.” Oncotarget, vol. 8,54 92890-92903. 6 Oct. 2017. DOI: 10.18632/oncotarget.21641

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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