Immuno-Oncology

With a growing demand for multiplex phenotyping and spatial analysis of the tumor microenvironment for immuno-oncology applications, Ultivue’s technology can help researchers gain a deeper understanding of the TME and immune response.

  • Tumor infiltration
  • Tumor proliferation
  • T cell activation
  • Immune suppression and exhaustion
  • Immune checkpoint access
  • Immune cell evasion

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Immune Infiltration

Distance mapping and proximity analysis of the tumor microenvironment can determine levels of immune infiltration. With single-cell resolution, the InSituPlex technology can provide detailed information for image analysis software to determine cell to cell interaction and possible immune infiltration.

Functional characterization of pro-tumor and anti-tumor phenotypes

With the ability to coexpress multiple markers on single cells, researchers can positively identify and confirm individual cell phenotypes as well as measure functional activity, e.g. CD3+ T-cells expressing and releasing Granzyme B.

Another example of immunophenotyping is demonstrated in a poster investigating the role of immunosuppressive macrophages (PD-L1+, CD68+)

Capturing the full range of expression of checkpoint markers

With the ability to visualize a dynamic range of certain marker expression (e.g. PD-L1 and PD-1) researchers can further define and identify the immune response to different targeted therapies. InSituPlex technology provides scientists with a true expression of dynamic range across all markers in a given assay – allowing for this extra in-depth investigation of the TME.

Explore our Technology

InSituPlex

Our proprietary InSituPlex technology enables unsurpassed biomarker detection and analysis in tissue, with no compromise on level of multiplexing, throughput of sample staining and imaging, and with no requirement of dedicated instrumentation.

Explore our Services

Standard and Custom Services

With speed and flexibility at heart, our Staining & Imaging services and Biomarker Programs offer highly customizable panels to include all your markers of interest.

product

Explore our Technology

InSituPlex

Our proprietary InSituPlex technology enables unsurpassed biomarker detection and analysis in tissue, with no compromise on level of multiplexing, throughput of sample staining and imaging, and with no requirement of dedicated instrumentation.

Services

Explore our Services

Standard and Custom Services

With speed and flexibility at heart, our Biomarker Programs offer 5-Plex validated and highly customizable panels to include all your markers of interest.

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