U-VUE Biomarker Datasheet - CD3

Target:CD3
Alternative Name:T-cell surface antigen T3
Clone:BC33
Isotype:Mouse IgG1
Reactivity:Human
Main cell types:T cell
Subcellular Location:Plasma membrane
Positive control:Tonsil, Spleen

CD3 is found on all mature T cells, serving important roles for T cell development. CD3 is part of the T cell receptor that recognizes antigen, resulting in the activation of signaling pathways. During T cell development the intensity of the response to antigen is tightly controlled to select for responsive T cells that are not autoreactive. In disease, the lack of CD3 expression is associated with a severe combined immunodeficiency (SCID) characterized by impairment of both humoral and cell-mediated immunity.

IHC: Anti-CD3 antibody [BC33] staining human tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-CD3 antibody conjugate [BC33] staining human tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-CD3 antibody conjugate [BC33] staining human tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Sathe, Anuja, et al. “Single Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment.” Clinical Cancer Research, American Association for Cancer Research, 1 Jan. 2020.  10.1158/1078-0432.CCR-19-3231

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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