Getting TiME on your side.
Turning colorful insight into meaningful impact.

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Revealing actionable biology with multiplex immunofluorescence

Ultivue seeks to make the promise of immuno-therapy a reality for every patient through rapid, precision profiling of tumor biology.

Multiplexing now gives you the power to visualize several biomarkers at once, enabling researchers to quickly elucidate the complex phenotypes of the tumor immune microenvironment (TiME) and advance research discoveries.

Reduce TAT in the lab by developing tailored optimized assays that can be applied to a broad range of cancer types and indications to characterize immune contexture.

CD8-labeled
IHC

CD3, Granzyme B,
SOX-10, DAPI

Cytotoxic T-cell mediated melanoma tumor cell death. In comparison to the limited information from single stain IHC (Left), Multiplexed Immunofluorescence (mIF) can capture an actionable biological event affording disease insight with spatial resolution. Here T cells demonstrate an immune response by recognizing and preparing to kill neighboring tumor cells: CD3-labeled T cells are seen releasing GrzB near SOX-10 labeled tumor cells.

Designed with translational researchers and pathologists in mind.

H&E

CD8, CD68, PD-L1, PanCK, DAPI

Co-registered stacked image of mIF

Whole Slide Scan ROI

Pathologists

Streamlined workflow
Whole-slide imaging
Non-disruptive staining
Same slide H&E compatible

Researchers

Rapid assay development
Fully customizable biomarkers
Uncover complex phenotypes
Advanced image analysis

Don’t go it alone: leveraging partnerships

Ultivue and its valued partners have established a seamless workflow integrating validated antibodies, state of the art chemistry and advanced analytics to drive personalized medicine.

With Ultivue, you know you’re getting the industry’s best at every step.

Antibodies

Abcam

Bethyl

Cell Signaling

Thermo Fisher

Stainers

Leica

Scanners

Olympus

Leica

Zeiss

Analysis

Indica Labs

VisioPharm

CRO's

Indivumed

OracleBio

Targos

Send us your sample, we’ll stain and analyze it for you.

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See for yourself

Ultivue is making an impact

Check out our catalogue of peer-reviewed publications and scientific presentations

PUBLICATIONS

Comparison of a novel multiplexed IF and cIHC addressing immune status in NSCLC

Kaiso: The link between autophagy, the TME, and breast cancer survival


-Nat. Commun. Biology 2021

A Phase 1B clinical trial for patients with advanced solid tumors​

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POSTERS

Characterizing spatial distribution of immune-cell subsets in Nonalcoholic Steatohepatitis and Primary Sclerosing Cholangitis using a novel 12-plex Ultimapper® kit

Enabling accurate cellular phenotyping using the InSituPlex technology technology with fast whole-slide scanning using ZEISS Axioscan.Z1

Optimized mIF using UltiMapper reagents with the ZEISS Axioscan 7 scanner

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WEBINARS

Advanced phenotyping of the tumor immune microenvironment

Using multiplexed Immunofluorescence for spatial quantification of immune cells

Combinatorial immunotherapy with advanced solid tumors

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