U-VUE Biomarker Datasheet - CD335

Target:CD335
Alternative Name:NCR1, NK-p46
Clone:195314
Isotype:Mouse IgG2b
Reactivity:Human
Main cell types:NK cells
Subcellular Location:Plasma membrane
Positive control:Tonsil, Spleen

CD335, also known as NKp46, belongs to the natural cytotoxicity receptor (NCR) family and it is selectively expressed on NK cells and a subset of NKT cells. It is involved in NK cell triggering of receptors recognizing non-MHC ligands during the process of natural cytotoxicity and tumor cell lysis by NK cells.

IHC: Anti-CD335 antibody [195314] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-CD335 antibody conjugate [195314] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-CD335 antibody conjugate [195314] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Hudspeth, Kelly et al. “Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways.” Journal of autoimmunity, vol. 66 (2016): 40-50. DOI: 10.1016/j.jaut.2015.08.011
  2. Messaoudene, Meriem et al. “Characterization of the Microenvironment in Positive and Negative Sentinel Lymph Nodes from Melanoma Patients.” PloS one, vol. 10,7 e0133363. 28 Jul. 2015. DOI: 10.1371/journal.pone.0133363
  3. Hervier, Baptiste, et al. “Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome.” The Journal of Immunology, American Association of Immunologists, 1 Sept. 2016. DOI: 10.4049/jimmunol.1501902

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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