U-VUE Biomarker Datasheet - Ki67

Target:Ki67
Alternative Name:MKI67
Clone:SP6
Isotype:Rabbit IgG
Reactivity:Human
Main cell types:Proliferating cells
Subcellular Location:Nuclear
Positive control:Tonsil, Spleen

Ki67 is a nuclear marker associated with cellular proliferation. Ki67 is present within the nucleus of cells undergoing division during interphase, but is absent in quiescent cells. Ki67 can also be used as a prognostic indicator in certain cancers.

IHC: Anti-Ki67 antibody [SP6] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-Ki67 antibody conjugate [SP6] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-Ki67 antibody conjugate [SP6] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Lim, Jing Shan et al. “Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.” Nature, vol. 545,7654 (2017): 360-364. DOI: 10.1038/nature22323
  2. Strietz, Juliane et al. “ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.” Oncotarget, vol. 7,50 (2016): 83278-83293. DOI: 10.18632/oncotarget.13086
  3. Zabaglo, Lila, et al. “Comparative Validation of the SP6 Antibody to Ki67 in Breast Cancer.” Journal of Clinical Pathology, BMJ Publishing Group, 1 Sept. 2010. DOI: 10.1136/jcp.2010.077578

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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