U-VUE Biomarker Datasheet - PD-1

Target:PD-1
Alternative Name:CD279, Programmed cell death 1
Clone:CAL20
Isotype:Rabbit IgG
Reactivity:Human
Main cell types:T cells
Subcellular Location:Plasma membrane
Positive control:Tonsil

Programmed cell death protein 1, also known as PD-1 and CD279, is an inhibitory receptor expressed by all T cells during activation. It regulates T cell effector functions during physiological responses, including acute and chronic infection, cancer and autoimmunity. When PD-1 is bound to his ligand PD-L1, it prevents T cells from killing target cells including cancer cells.

IHC: Anti-PD-1 antibody [CAL20] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-PD-1 antibody conjugate [CAL20] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-PD-1 antibody conjugate [CAL20] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Sathe, Anuja, et al. “Single Cell Genomic Characterization Reveals the Cellular Reprogramming of the Gastric Tumor Microenvironment.” Clinical Cancer Research, American Association for Cancer Research, 1 Jan. 2020.  10.1158/1078-0432.CCR-19-3231

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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