U-VUE Biomarker Datasheet - SOX10

Target:SOX10
Alternative Name:Transcription factor SOX-10
Clone:BC34
Isotype:Mouse IgG1
Reactivity:Human
Main cell types:Melanocytes
Subcellular Location:Nuclear
Positive control:Normal Skin, Melanoma

SOX10 (Sry-related HMg-Box gene 10) is a nuclear transcription factor invovled in differentiation of neural crest progenator cells to melanocytes and maintanace of Schwann cells. Its high expression is observed in the melanocytic tumors of skin, soft tissue and primary as well as metastatic melanoma.

IHC: Anti-SOX10 antibody [BC34] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

IHC: Anti-SOX10 antibody conjugate [BC34] staining normal tonsil FFPE tissue (brown). Hematoxylin counterstain in blue.

ISP: Anti-SOX10 antibody conjugate [BC34] staining normal tonsil FFPE tissue (green). Nuclear counterstain in blue.

References

  1. Tacha, D, et al. “A Newly Developed Mouse Monoclonal SOX10 Antibody Is a Highly Sensitive and Specific Marker for Malignant Melanoma, Including Spindle Cell and Desmoplastic Melanomas.” Archives of Pathology & Laboratory Medicine, Archives of Pathology and Laboratory Medicine, Apr. 2015. DOI: 10.5858/arpa.2014-0077-OA
  2. Halse, H., et al. “Multiplex Immunohistochemistry Accurately Defines the Immune Context of Metastatic Melanoma.” Nature News, Scientific Reports, 24 July 2018. DOI: 10.1038/s41598-018-28944-3
  3. Røge, R, et al. “NordiQC Assessments of SOX10 Immunoassays.” Applied Immunohistochemistry & Molecular Morphology : AIMM., AIMM, July 2017. DOI: 10.1097/PAI.0000000000000536

Verification

Each lot of antibody conjugate reagent is quality control tested on positive control tissue and reviewed by Ultivue’s Pathology and Biomarker Analytics group to ensure appropriate staining patterns and signal intensity.

This U-VUE Antibody Conjugate is for Research Use Only. Not for Diagnostic purposes.

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