Assay Development & Services

Transparency and open communication are among the key principles that guide our services team to ensure your needs are met.

Our areas of expertise include:

Assay Design and Development
Proof-of-Concept (PoC) Design and Execution
Concordance Studies
Assay Verification/Validation
Clinical Trial Support

An end-to-end solution empowers your team to attain quantitative insights in a fraction of the time, without in-house development costs.

Quantifiable assay service experience

20 top pharmaceutical companies in collaboration with Ultivue, worldwide.

150+ projects successfully completed.

53 ongoing projects including Phase I and Phase II clinical trials.

175+ unique biomarkers developed.

150+ custom VUE panels.

250+ unique projects for 70+ different clients.

Gain more insights from a single slide

12-plex OmniVUE™ and U-VUE^® panels available as a service

Learn more about 12-plex assay services

Integrated Assay Services

Assay Development Milestones

Assay Development 

· Antibody Verification
· Barcode conjugation
· Verification of conjugates

Panel Development

· Assay Development
· Optional sample testing

Staining & Imaging 

· Verify sample integrity
· Stain samples
· Control testing

Image Analysis 

· Phenotypes
· Regions
· Advanced analytics
· Data mining

Talk to our experts

Our pathologists, histopathology experts, and image analysis and AI scientists ensure that your scientific research needs are met. The same experts are involved throughout the entire length of a project ensuring consistency from project inception all the way to delivery of the results.

Talk to a Biomarker Expert

Your research goals are time-sensitive.

Let us support you in investigating your novel hypothesis by obtaining the most informative data from your valuable samples using InSituPlex^® technology and whole slide imaging (WSI). In partnership with our team of histopathology experts, we will help advance your specific research needs.

H&E staining and mIF on one slide.

Instead of staining and assessing just one or two protein biomarkers at a time or even multiple markers throughout a set of serial sections, InSituPlex^® technology allows for multiple biomarkers coupled to traditional H&E staining to be visualized and quantified using just a single tissue slide.

Collaborative partnership for your assay development.

With In-house expertise in both IHC and multiplex immunofluorescence (mIF) assay development, customers can expect a unique experience with the Ultivue service team. Working in an agile and collaborative environment, get quick custom assay development and optimization.

Scientific expertise from start to finish.

The same expert IHC scientists are involved throughout the entire length of a project ensuring consistency from project inception all the way to delivery of the results.

GCP-compliant lab.

Ultivue’s Assay Development & Services lab is a GCP-compliant lab, ensuring regulatory compliance and data integrity for your projects. Rest assured that you will receive accurate, reliable, and timely test results.

InSituPlex® Technology

Why Tissue Plex with InSituPlex®?

Ultivue provides researchers and scientists with multiplex biomarker assays and advanced image informatics for tissue phenotyping and digital pathology. Our proprietary InSituPlex^® technology enables advanced exploration and interrogation of tissue samples for precision medicine research. These highly customizable solutions and scientific consultative approach strengthen and accelerate biomarker discovery and drug development programs.

InSituPlex^® technology requires only a single antigen retrieval step before applying a mixture of DNA-barcoded antibodies, which then bind to the desired array of antigens. After amplification, fluorescent probes are attached to those barcodes, allowing for visualization of the model using fluorescent microscopy. The InSituPlex^® technology is available in up to 12-plex panel options.

Learn more about our technology

Sample fully preserved

Outstanding retention of sample antigenicity and minimization of antibody steric hinderance in the mIF staining process.

Compatible with conventional pathology

Co-registration of mIF and H&E images acquired from the same slide

Sample standardized tissue multiplexing

Reproducibility of fixed, flexible or custom biomarker panels across disease indications.

Amenable to high-throughput

Minimal ‘Sample-to-Answer’ time for whole slide imaging. Plex options 4, 8 and 12-plex.

Agnostic

Instrument agnostic without the need for re-optimization.

Scalable Implementation

Transferable biomarker panels to CRO outsourcing partners for clinical research roll-out.

Not sure where to start?

We can help you to scope your project and discuss timelines and deliverables.

Assay Development | Image Analysis | Data Mining

Talk to a Biomarker Expert

Assay Development & Services

Transparency and open communication are among the key principles that guide our services team to ensure your needs are met.