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Cell Phenotypes Cell Phenotyping with the PD-L1 FixVUE Panel
The antibody panel in the PD-L1 FixVUE enables users to detect immune infiltration and profile tumor samples. CD8 is a marker for cytotoxic immune cells (mainly cytotoxic T cells). CD68
is a marker for macrophages. PD-L1 is an immune checkpoint marker that can be expressed on both macrophages and tumor cells. SOX10 is a tumor marker for melanomas while panCK detects carcinomas; antibodies for panCK and SOX10 are provided as a cocktail in this panel. The expression level of PD-L1+ tumor cells and their proximity to CD8+ T cells have been highlighted as potential predictors of therapeutic response.
Our Technology
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antibody selection and biomarker strategy: ensure that your design a panel optimized for the best data
assay development: get assistance to ensure that your assay will translate from research to clinical use
pathological assessment: our pathologists can assist with tailoring your project to maximize its relevance
image and data analysis: computational expertise to find the key features and develop robust algorithms
FlexVUE
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Show moreProduct Biology
Markers
Main Cell Type
Markers,Main Cell Type
CD3
T cells
CD3, T cells
Identifies all T cells and is the most specific marker for T cells, including lineage based markers such as CD4 and CD8.
CD4
Helper T cell
CD4, Helper T cell
CD4 binds to MHC class II molecules and participates in signal transduction processes. Its expression is used to identify helper T cells of which there are many different subsets each contributing to the overall immune function through their unique cytokine profile.
CD8
Cytotoxic T cells
CD8, Cytotoxic T cells
Cytotoxic T cells are responsible for mediating apoptosis of cancer cells through a variety of mechanisms that include the release of granzyme B from the T cells.
CD68
Marophages
CD68, Marophages
CD68 is expressed on human macrophages and other mononuclear phagocytes. CD68 functions in phagocytic activities and macrophage homing. An increased CD68+ macrophage index is associated with metastasis, poor prognosis, and reduced overall survival in multiple types of cancer.
FoxP3
Regulatory T cell
FoxP3, Regulatory T cell
FoxP3 is a transcription factor important in the development and inhibitory function of regulatory T cells (Tregs). FoxP3 functions by inhibiting cytokine production and T cell effector function, thus playing a crucial role in maintenance of immunological tolerance and control of immune responses against tumors and pathogens.
PD-1
Exhausted T cell
PD-1, Exhausted T cell
Programmed death receptor-1 (PD-1), an immune checkpoint molecule, is over expressed in cancer, leading to increased T cell exhaustion and a decreased anti-tumor response.
PD-L1
T cells, Monocytes, NK cells and Macrophages
PD-L1, T cells, Monocytes, NK cells and Macrophages
PD-L1 is expressed on the surface of tumor cells and it is able to bind to PD-1 on the surface of activated T cells and B cells. The binding of PD-L1 to PD-1 leads to an immunosuppressive effect and allows the tumor to evade immune destruction.
CK/SOX10
Tumor cells
CK/SOX10, Tumor cells
Cytokeratins are expressed in cells of an epithelial origin including most carcinomas. Sox10 is expressed in cells derived from the neural crest including melanocytes that give rise to melanomas.
Markers
Phenotype |
CD3 | CD4 | CD8 | FoxP3 | PD-1 | PD-L1 | CK/SOX10 |
T cells |
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T helper cells |
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Cytotoxic Immune cells |
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Phenotype
Markers
Headline
Phenotype, Markers
T cells
T helper cells
Cytotoxic Immune cells
4444
5555
6666
7777
Markers
Phenotype |
CD3 | CD4 | CD8 | CD68 | FoxP3 | PD-1 | PD-L1 | panCK/SOX10 |
T cells |
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This multiplexed immunofluorescence (mIF) panel allows for the spatial identification of single biomarkers and co-expression of multiple markers in cells enabling the observation of several biologically relevant phenotypes. The above is a partial of the 256 distinct binary phenotypes that this panel can identify. The number of phenotypes increases if binned marker intensities are taken into account (e.g. PD-1, PD-L1, FoxP3 expression levels).
Phenotype
Cytotoxic Immune cells
Headline
Phenotype, Markers
T cells
T helper cells
Cytotoxic Immune cells
Markers
Phenotype |
CD3 | CD4 | CD8 | CD68 | FoxP3 | PD-1 | PD-L1 | panCK/SOX10 |
bnnPhenotype |
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Phenotype
bnnPhenotype
Headline
Phenotype, Markers
bnnPhenotype
Service-Levels
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FAQ
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