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poster

Presented at: EASL 2021

Characterizing spatial distribution of immune-cell subsets in Nonalcoholic Steatohepatitis and Primary Sclerosing Cholangitis using a novel 12-plex Ultimapper ® kit

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Relevant for

FixVUE, InSituPlex

Discription

  • Inflammation is a key driver for the progression of chronic liver diseases, which are characterized by parenchymal cell injury, immune-cell infiltration, and fibrogenesis1
  • No pharmacologic treatment options exist for nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) at present
  • Understanding the contributors and overlap in the immune landscape in NASH and PSC can provide a basis to develop new therapies

Authors

Milessa Silva Afonso, Abhishek Aggarwal, David Lopez, Adrien Guillot, Marc Winkler, Swetha Pendem, Sangeetha Mahadevan, Frank Tacke, Lauri Diehl and Ruchi Gupta

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