poster
Presented at: EASL 2021
Characterizing spatial distribution of immune-cell subsets in Nonalcoholic Steatohepatitis and Primary Sclerosing Cholangitis using a novel 12-plex Ultimapper ® kit
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Relevant for
FixVUE, InSituPlex
Discription
- Inflammation is a key driver for the progression of chronic liver diseases, which are characterized by parenchymal cell injury, immune-cell infiltration, and fibrogenesis1
- No pharmacologic treatment options exist for nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) at present
- Understanding the contributors and overlap in the immune landscape in NASH and PSC can provide a basis to develop new therapies
Authors
Milessa Silva Afonso, Abhishek Aggarwal, David Lopez, Adrien Guillot, Marc Winkler, Swetha Pendem, Sangeetha Mahadevan, Frank Tacke, Lauri Diehl and Ruchi Gupta
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