shape Monitor
Angela Vasaturo, PhD; Lorcan Sherry, PhD

Associate Director Scientific Affairs, Ultivue; Chief Science Officer, OracleBio

Living in a Spatial World: Characterizing the Immune Environment in Tumors

77 minutes

Relevant for


Description Immunotherapy has transformed the treatment of metastatic and recurrent solid tumors. Advances in technology in the past few years have created unprecedented opportunities to better identify biomarkers of disease processes, especially by using multi-omics technologies and datasets to derive valid and useful signatures of disease. Despite these advances, today only a minority of patients respond to immunotherapies. Prediction of response to therapies such as checkpoint inhibitors that rely on activation of endogenous immune responses has been shown to be especially difficult due to complex and heterogeneous immune escape mechanisms in each patient. Increasing evidence suggests that measurement of robust biomarkers through spatial analysis of the tissue will be key to enable rational patient selection for an improved clinical trial process and design precise combination therapies. To date, much of what has been learned about the tumor microenvironment (TME) has come from the use of IHC, but information has been limited by labor-intensive protocols that yield single data points. IHC method sare therefore not sufficient for generating the comprehensive and interactive picture of the TME landscape. Newer technological approaches, such as multiplex immunofluorescence (mIF), provide greater resolution, better use of precious samples, and unparalleled insight into the spatial cellular arrangement within the tumor. The quantitative assessment of the accuracy and precision of such multiplex panels however is key for their widespread use in clinical samples.

Webinar Learning Objectives

The development and validation process of a high throughput, high-plex mIF assay to derive meaningful biological insights.

Demonstrate how advanced AI-driven image analysis can be applied to discover cell types, populations and morphological context.

Discuss how whole slide image analysis of the tumor microenvironment can provide insight into specific cancer types.

Meet the hosts

Angela Vasaturo is the Associate Director Scientific Affairs at Ultivue. Prior to joining Ultivue she was a Senior Researcher in Dr. Jerome Galon’s Laboratory of Integrative Cancer Immunology at the Cordeliers Research Centre. She has a wealth of expertise in multiplex IHC techniques, multispectral digital pathology, and tissue imaging.

Angela Vasaturo, PhD

Associate Director Scientific Affairs, Ultivue

Lorcan is an image analysis expert who previously spent 10 years in the pharmaceutical industry as a group leader (Organon, Schering-Plough, Merck & Co.). He led a group responsible for performing histology, immunohistochemistry / image analysis and he has considerable experience in developing translational biomarker strategies for projects across various therapeutic areas. He is a Prince 2® qualified project manager and has extensive experience in study management.

Lorcan Sherry, PhD

Chief Science Officer, OracleBio