Assay development
5880 Getting TiME on Your Side: Defining the future of precision medicine with advanced multiplexed immunofluorescence
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Getting TiME on Your Side: Defining the future of precision medicine with advanced multiplexed immunofluorescence

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FixVUE, InSituPlex, U-VUE

Description Overview highlighting the use of the InSituPlex® (ISP) a novel, robust mIF assay technology reliant on conjugating DNA barcodes to antibodies and using sequence-specific DNA-DNA hybridization tolabel antibodies for spatial profiling of immuno-oncology targets in FFPE tumor tissue

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5824 Comparative multiplex digital phenotyping of the tumor microenvironment across multiple tumor types using a well characterized multi-tumor tissue microarray
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poster

Presented at: AACR 2021

Comparative multiplex digital phenotyping of the tumor microenvironment across multiple tumor types using a well characterized multi-tumor tissue microarray

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Relevant for

Collaboration, FixVUE, InSituPlex

Description The tumor microenvironment (TME) represents a complex interaction of immune and host cellsand can be described broadly as ‘inflamed’, ‘immune excluded’ and ‘desert’; categories that mayserve as predictive parameters for response to different immunotherapies. Multiplexedfluorescence and associated digital imaging platforms are important tools for defining the spatialcomponents of the TME and can accelerate development of novel immunotherapy strategies.

Authors

Marie Cumberbatch, Douglas Wood, Christopher Womack, Milan Bhagat, Angela Vasaturo, Mael Manesse and Lorcan Sherry (TriStar, OracleBio)

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5867 High-multiplex automated staining and scanning workflow with Ultivue InSituPlex technology and the Olympus SLIDEVIEW VS200 slide scanner
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Presented at: AACR 2020

High-multiplex automated staining and scanning workflow with Ultivue InSituPlex technology and the Olympus SLIDEVIEW VS200 slide scanner

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Relevant for

Collaboration, FixVUE, InSituPlex

Authors

Amanda Bares, Alec De Grand, Douglas Wood and Maël Manesse

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5865 Gene Expression Profiling, Digital Spatial Profiling and Multiplex Immunohistochemistry of the Tumor-Immune Microenvironment in HNSCC Tumors
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Presented at: AACR 2021

Gene Expression Profiling, Digital Spatial Profiling and Multiplex Immunohistochemistry of the Tumor-Immune Microenvironment in HNSCC Tumors

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Relevant for

Collaboration, FixVUE, InSituPlex

Description The tumor microenvironment (TME) represents a complex interaction of immune and host cellsand can be described broadly as ‘inflamed’, ‘immune excluded’ and ‘desert’; categories that mayserve as predictive parameters for response to different immunotherapies. Multiplexedfluorescence and associated digital imaging platforms are important tools for defining the spatialcomponents of the TME and can accelerate development of novel immunotherapy strategies.

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5861 Introduction of a robust workflow for the whole whole-side acquisition and co-registration of multiplex immunofluorescence tissue images for analysis of a 9-color, 8-marker immunophenotyping assay
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Presented at: AACR 2021

Introduction of a robust workflow for the whole whole-side acquisition and co-registration of multiplex immunofluorescence tissue images for analysis of a 9-color, 8-marker immunophenotyping assay

Register here for download

Relevant for

Collaboration, FixVUE, InSituPlex

Description The tumor microenvironment (TME) represents a complex interaction of immune and host cellsand can be described broadly as ‘inflamed’, ‘immune excluded’ and ‘desert’; categories that mayserve as predictive parameters for response to different immunotherapies. Multiplexedfluorescence and associated digital imaging platforms are important tools for defining the spatialcomponents of the TME and can accelerate development of novel immunotherapy strategies.

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5855 Sequential same slide multiplex immunofluorescence and H&E staining for combined phenotypic and morphologic characterization of formalin-fixed paraffin-embedded tissue sections
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Presented at: AACR 2021

Sequential same slide multiplex immunofluorescence and H&E staining for combined phenotypic and morphologic characterization of formalin-fixed paraffin-embedded tissue sections

Register here for download

Relevant for

Collaboration, FixVUE, InSituPlex

Description The tumor microenvironment (TME) represents a complex interaction of immune and host cellsand can be described broadly as ‘inflamed’, ‘immune excluded’ and ‘desert’; categories that mayserve as predictive parameters for response to different immunotherapies. Multiplexedfluorescence and associated digital imaging platforms are important tools for defining the spatialcomponents of the TME and can accelerate development of novel immunotherapy strategies.

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5846 Utilizing image analysis to characterize an 8-plex immunofluorescence immune checkpoint biomarker panel within the tumor tissue microenvironment
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Presented at: AACR 2021

Utilizing image analysis to characterize an 8-plex immunofluorescence immune checkpoint biomarker panel within the tumor tissue microenvironment

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Relevant for

Collaboration, InSituPlex

Description The tumor microenvironment (TME) represents a complex interaction of immune and host cellsand can be described broadly as ‘inflamed’, ‘immune excluded’ and ‘desert’; categories that mayserve as predictive parameters for response to different immunotherapies. Multiplexedfluorescence and associated digital imaging platforms are important tools for defining the spatialcomponents of the TME and can accelerate development of novel immunotherapy strategies.

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5874 Introduction of a robust workflow for the whole-slide acquisition and co-registration of multiplex immunofluorescence tissue images for analysis of a 9-color, 8-marker immunophenotyping assay
shape book
ebook

Introduction of a robust workflow for the whole-slide acquisition and co-registration of multiplex immunofluorescence tissue images for analysis of a 9-color, 8-marker immunophenotyping assay

Register here for download

Relevant for

Collaboration, FixVUE, InSituPlex

Description Overview highlighting the use of the InSituPlex® (ISP) a novel, robust mIF assay technology reliant on conjugating DNA barcodes to antibodies and using sequence-specific DNA-DNA hybridization tolabel antibodies for spatial profiling of immuno-oncology targets in FFPE tumor tissue

Authors

Anne Hellebust, Kyla Teplitz, Katir K Patel, Karan Sharma, Amanda Bares, Mael Manesse, Mark Burton, Bonnie Phillips, Sean Downing and Kate Lillard

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5863 Looking beyond the assay: Comparison of multiplex chromogenic and fluorescent immuno-histochemistry for standardized immune oncology profiling in non-small cell lung carcinoma patients
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Presented at: AACR 2021

Looking beyond the assay: Comparison of multiplex chromogenic and fluorescent immuno-histochemistry for standardized immune oncology profiling in non-small cell lung carcinoma patients

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Relevant for

Collaboration, FixVUE, InSituPlex

Description The tumor microenvironment (TME) represents a complex interaction of immune and host cellsand can be described broadly as ‘inflamed’, ‘immune excluded’ and ‘desert’; categories that mayserve as predictive parameters for response to different immunotherapies. Multiplexedfluorescence and associated digital imaging platforms are important tools for defining the spatialcomponents of the TME and can accelerate development of novel immunotherapy strategies.

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5821 A phase I clinical trial on intratumoral administration of autologous CD1c (BDCA-1)+ myeloid dendritic cells (myDC) plus talimogene laherparepvec (T-VEC) in patients with advanced melanoma
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Presented at: AACR 2021

A phase I clinical trial on intratumoral administration of autologous CD1c (BDCA-1)+ myeloid dendritic cells (myDC) plus talimogene laherparepvec (T-VEC) in patients with advanced melanoma

Register here for download

Relevant for

FixVUE, InSituPlex

Description The tumor microenvironment (TME) represents a complex interaction of immune and host cellsand can be described broadly as ‘inflamed’, ‘immune excluded’ and ‘desert’; categories that mayserve as predictive parameters for response to different immunotherapies. Multiplexedfluorescence and associated digital imaging platforms are important tools for defining the spatialcomponents of the TME and can accelerate development of novel immunotherapy strategies.

Authors

Marie Cumberbatch, Douglas Wood, Christopher Womack, Milan Bhagat, Angela Vasaturo, Mael Manesse and Lorcan Sherry (TriStar, OracleBio)

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5827 Use of Ultivue InSituPlex®Multiplex Immunofluorescence to Localize and Quantify Regulatory T Lymphocytes in Crohn’s Disease and Ulcerative Colitis
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Presented at: AACR 2021

Use of Ultivue InSituPlex®Multiplex Immunofluorescence to Localize and Quantify Regulatory T Lymphocytes in Crohn’s Disease and Ulcerative Colitis

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Relevant for

Collaboration, FixVUE, InSituPlex

Description The tumor microenvironment (TME) represents a complex interaction of immune and host cellsand can be described broadly as ‘inflamed’, ‘immune excluded’ and ‘desert’; categories that mayserve as predictive parameters for response to different immunotherapies. Multiplexedfluorescence and associated digital imaging platforms are important tools for defining the spatialcomponents of the TME and can accelerate development of novel immunotherapy strategies.

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

Categories: 5882 Case Study: A multiplex immunofluorescence assay to assess immune checkpoint inhibitor-targeted CD8 activation and tumor co-localization in FFPE tissues
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ebook

Case Study: A multiplex immunofluorescence assay to assess immune checkpoint inhibitor-targeted CD8 activation and tumor co-localization in FFPE tissues

Register here for download

Relevant for

Collaboration, FixVUE, InSituPlex

Description Overview highlighting the use of the InSituPlex® (ISP) a novel, robust mIF assay technology reliant on conjugating DNA barcodes to antibodies and using sequence-specific DNA-DNA hybridization tolabel antibodies for spatial profiling of immuno-oncology targets in FFPE tumor tissue

Want to meet with us? Check out our upcoming events.

Want to meet with us? Check out our upcoming events.

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